Gene profiling of B lymphoblastoid cell lines from DRESS patients after drugs incubation
نویسندگان
چکیده
Background Drug reaction with eosinophilia and systemic symptom (DRESS) is a severe drug-induced cutaneous reaction with visceral involvement and blood abnormalities associated with reactivations of herpes-virus family i.e., EBV, HHV-6, HHV-7 and CMV. Recently, we demonstrated that the immune response in DRESS, previously thought to be directed only against drug components, is also mediated by herpes-virus specific cytotoxic CD8+ T lymphocytes which home to the skin and visceral organs.
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Drugs responsible of DRESS syndrome regulate IL-10 and TNF-α secretion
Background Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe drug-induced reaction that involves both the skin and the viscera. Several herpesvirus family members like EBV or HHV-6 can be detected coincidently with various clinical symptoms in DRESS. In addition, we have previously identified activated EBV specific cytotoxic CD8+ T cells as major actors in the pathophysi...
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